The integration of longitudinal genetic and epigenetic studies into routine pharmaceutical safety evaluation is a critical and glaring knowledge gap that demands urgent attention within drug development and post-marketing surveillance pipelines. Despite the rapid advancement in genetic, epigenetic, and neuro- sciences enabling unprecedented molecular insight, current safety assessments largely overlook the cumulative and nuanced molecular impacts of chronic drug exposure, thereby potentially perpetuating unforeseen risks to patient safety and public health. This lack of progressive integration underscores profound ethical and scientific shortcomings that risk undermining both patient trust and optimal therapeutic outcomes.
Explanata Penultimata (09-30-2025)
1:00:00m (aka “Step 1: My Gifts) – spoken daily journal; morning thoughts, end of year practices, first step – acknowledging my gifts; career frustrations and explanation of the penultimate day and how I’m getting started earlier because… reasons.
An Autistic American Moment (43:37m)
43:37m – spoken audio on the matter of being an autistic amercian in this moment, lived experience exposition, and as always, related neuroscience and genetics/epigenetic thoughts.
The ‘Sacred Triad of Being’ & The Importance of Your ‘Why’
Much of the deepest wisdom in life arrives in deceptively simple packaging. Ancient cultures often distilled immense truths into symbols, short sayings, or small practices that contain layer upon layer of meaning. What initially appears simple often turns out to be what I think of as a Matryoshka doll of concepts; ideas nested within ideas, each entangled with larger social, cultural, and even biological systems. This is how the concept of the Sacred Triad of Being emerged for me. It is at once individual and collective, personal and political, psychological and philosophical. The triad is composed of three equilateral spheres […]
Ignore the propaganda/media (all you need to know is…)
(audio courtesy of https://notegpt.io – a free online text to speech generator) Captive, coerced, and controlled labor is the grail of economy. Cheap, captive, coerced, and controlled labor is the grail of capitalism. Cowed, cheap, captive, coerced, and controlled labor is the grail of power. Consider the focus and locus of all this activity and effort — it is enlightening: All economy stops without labor. Global Capitalism fails without labor. All Power crumbles without labor. If you sell your labor, every bit of the above is targeting you. Economy, Global Capitalism, Power, they ALL know their entire kingdom rests upon […]
#Registered TYS and thoughts
It’s April 15, 2025, and the United States is collapsing, practically in real-time. There is an authoritarian, dictatorial, and utterly vindictive man child holding the highest position in our country. They were elected to it by the fascist, racist, and generally self-centered ‘white’ ignorance, a majority within the country. But it seems the federal government has held many fascist, racist, and self-centered ‘white’ intelligentsia for decades; seemingly waiting for the opportunity to ‘restore’ themselves to power and return any who are not part of this deviant ‘us’ to sub-humanized placements, beholden to them for life itself. This pattern has been […]
Track title: This Is Fascism
ASCAP Registraton #: 929458861 This is fascism and it wants to come and stay To run our lives, take them too, as whim may Detained Prison slavery for any who naysay Command and control – it’s the game they play They’re yanking people off of our streets Think they’re allowed cuz they’re ‘the elites’ Not you they care for, just labor you can give If they like how you kiss the ring, you get to live Ontologically, they murder all dissent They act the same, this is their remit: Where are your papers? Prove yourself to me! What are you […]
My thoughts on “Fight Oligarchy” tour stop: Vegas (1st Half Reaction Audio)
I am ignorant too, just like any other human. I mis-named this woman and I should have looked it up before getting started, but the thought was overflowing and I made a call and this is the result. I will do better. My apologies to Alexandria Ocasio-Cortez, Congresswoman for the Bronx and Queens.
Track Title: Democracy’s Swan Song
I rarely preface these, but here I am, doing just that. If anyone out there wants to make this a real song, please connect via the contact form here or reach out on Blueksky (@yeshes.online). ASCAP Registration #: 929282710 Mobility is your inherent right!!!! Is this Nazi Germany?!?!?! Must my papers be in sight?!?! Their jack-boots slapping They walk down our streets Their hatred stamping Our rights beneath… Seeking out the different Getting more vociferant Prison complex so clinquant Always wanting what you got Rights actively they supplant Will you comply? I know I just can’t. Attacking the ideals that […]
Why I stay with Bluesky
Sharing the SWSX live stream because when you compare this narrative to the ones of the other platforms, particularly its currently open and free access and personalizing configuration (still unfolding), it becomes clear this is emergent possibility for better and more refined functionality than we’ve managed to see scale successfully. It’s an exciting time. Lots of opportunity. I’ve been yelling since the BBS days about the need to stipulate and protect a concept that is today called ‘protocols’ (that’s another article) as an emergent technology that genuinely can and likely will return personal power and certainly digital dignity (not Lanier’s […]